BRCA2 Rabbit pAb
Cat No.: APA1008
Size：
| Product Name: | BRCA2 Rabbit pAb |
| Cat No.: | APA1008 |
| source: | Rabbit |
| reactivity: | Human |
| applications: | WB |
| clonality: | Polyclonal |
| recommended dilution: | WB: 1:1000 |
| format: | Liquid |
| isotype: | IgG |
| immunogen: | A synthetic peptide of human BRCA2 |
| calculated molecular weight: | 384 kDa |
| observed molecular weight: | 384 kDa |
| genbank accession number: | P51587 |
| gene id (ncbi): | 675 |
| purification method: | Affinity Purification |
| conjugate: | Un-conjugated |
| storage: | Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
| synonyms: | FAD; FACD; FAD1; GLM3; BRCC2; FANCD; PNCA2; FANCD1; XRCC11; BROVCA2 |
| category: | Primary Ab |
| concentration: | 0.5mg/ml |
| background: | Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The largest exon in both genes is exon 11, which harbors the most important and frequent mutations in breast cancer patients. The BRCA2 gene was found on chromosome 13q12.3 in human. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, May 2020] |