Purified Anti-Mouse TCR γ/δ Antibody[UC7-13D5]
Cat No.: FCE2743
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| Product Name: | Purified Anti-Mouse TCR γ/δ Antibody[UC7-13D5] |
| Cat No.: | FCE2743 |
| host: | Armenian Hamster |
| uniprot id: | |
| geneid: | 110066,110067 |
| application: | FCM |
| isotype: | Armenian Hamster IgG |
| form: | Liquid |
| storage: | This product can be stored at 2-8°C for 12 months. Do not freeze. |
| shipping: | Ice bag |
| category id: | Flow Cytometry Antibodies |
| abbreviation: | TCR γ/δ |
| conjugation: | Unconjugated |
| species reactivity: | Mouse |
| usage: | Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 10^6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. |
| clone no.: | UC7-13D5 |
| background: | T cell receptor (TCR) is a heterodimer consisting of an α and a β chain (TCR α/β) or a γ and a δ chain (TCR γ/δ). TCR γ/δ belongs to the immunoglobulin superfamily, involved in the recognition of certain bacterial and tumor antigens bound to MHC class I. The TCR γ/δ associates with CD3 and is expressed on a T cell subset found in the thymus, the intestinal epithelium, and the peripheral lymphoid tissues and peritoneum. Most γ/δ T cells are CD4-/CD8-, some are CD8+. T cells expressing the TCR γ/δ have been shown to play a role in oral tolerance, tumor-associated tolerance, and autoimmune disease. It has been reported that γ/δ T cells also play a principal role in antigen presentation. Immobilized UC7-13D5 antibody has been reported to activate TCR-γ/δ-bearing T cells in vitro, and to deplete peripheral TCR-γ/δ-bearing T cells in vivo. |
| target synonym: | TCR-γ/δ; γ/δ TCR; |
| concentration: | 0.5 mg/mL |
| buffer: | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer. |
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