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IL-2 Receptor alpha Rabbit pAb

Cat No.: APA1003
Product Name: IL-2 Receptor alpha Rabbit pAb
Cat No.: APA1003
source: Rabbit
reactivity: Human, Mouse, Rat
applications: WB, IHC, ICC/IF
clonality: Polyclonal
recommended dilution: WB: 1:1000
IHC: 1:200
ICC/IF: 1:200
format: Liquid
isotype: IgG
immunogen: A synthetic peptide of human IL-2 Receptor alpha
calculated molecular weight: 31 kDa
observed molecular weight: 40-80 kDa
genbank accession number: P01589, P01590, P26897
gene id (ncbi): 3559, 16184, 25704
purification method: Affinity Purification
conjugate: Un-conjugated
storage: Store at -20°C. Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
synonyms: p55; CD25; IL2R; IMD41; TCGFR; IDDM10
category: Primary Ab
concentration: 0.5mg/ml
background: The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. Patients with severe Coronavirus Disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have significantly elevated levels of IL2R in their plasma. Similarly, serum IL-2R levels are found to be elevated in patients with different types of carcinomas. Certain IL2RA and IL2RB gene polymorphisms have been associated with lung cancer risk. [provided by RefSeq, Jul 2020]